Comment on: The effects of green tea consumption on metabolic and anthropometric indices in patients with type 2 diabetes

| December 2014 | 1203 in the elderly. [9] They found the positive effective of green tea in inducing weight loss, reducing body mass index and waist circumference in elderly patients with metabolic syndrome.[9] Similarly, Mozaffari-Khosravi et al. examined the effects of green tea and sour tea on blood pressure of patients with type II diabetes mellitus by a randomized clinical trial on 100 mildly hypertensive patients. They found that mildly hypertensive type II diabetic individuals who drank three glasses of green or sour tea, daily for 4 weeks, showed significant decrease in systolic and diastolic blood pressures. [10] Thus, consumption of green tea for the treatment of hypertension, further, protects kidney in diabetic patients.[2,7-9] In diabetic kidney disease, the glomeruli has been at the focus of attention as the primary site of injury in diabetic nephropathy. Conversely, it is well known that tubulointerstitial alterations are notorious components of the disease, especially in patients with type II diabetes.[1-7] The amounts of proteinuria and diabetic nephropathy progression are finely associated with tubular injury and interstitial fibrosis.[5-7] Indeed, urinary biomarker data in human beings offer the inspection that proximal tubule injury contributes in a main key, rather than in a secondary manner, to the development of early diabetic nephropathy.[7-9] Actually, in the process of diabetic kidney disease, capillary rarefaction leads to local ischemia with additional damage to the tubules, additional profibrogenic mediator of fibrosis, matrix protein deposition and acceleration of the glomerulosclerosis.[3-6] Thus, in diabetic nephropathy, the tubules show changes that are usually correlated with glomerular alterations, tubular cell degeneration, tubular apoptosis, and tubular atrophy.[6-10] Hence, it is rational to interpret that green tea has two different roles: 1. Tubular protection by acting as an effective antioxidant. 2. Ameliorative effects on metabolic and anthropometric indices as well as level of blood pressure which indirectly protect the kidney against nephropathy of diabetes.